"I didn't need saving, Torn." Polycythemic animals may remain asymptomatic for weeks to years and, in some cases, can be successfully managed for years. Welcome to Jak II HD!Originally released as Jak II: Renegade in 2003 on the Playstation 2, this HD re-release gives you the chance to join Jak and Daxter on their second adventure in the series, which is set in the city of New Haven far into the future from the previous game. This is usually due to a decrease in plasma volume associated with severe dehydration or increased serum total proteins, e.g., profound vomiting and diarrhea, or severe burns. Jak 2 used the groundwork laid by the first game and greatly expanded on it. Long-term follow up has not been reported in animals, although the author has observed persistent polycythemia for more than a decade in certain animals. Meeting up at the power station, Vin tells Jak and Daxter that they must destroy the dark eco wells at the strip mine, or else they'll attract more Metal Heads. Chemotherapy with hydroxyurea at 10–25 mg/kg twice daily to once every other day is commonly used. Because of an underappreciation of the normal upper limit of the PCV in cats (48%) versus dogs (56%), polycythemia is generally underdiagnosed in cats. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of erythrocytosis. School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphia, PA, USA. Average score of 5 user reviews. Vin appears to be elderly given his gray hair and slightly aged skin, though his age is hard to tell due to his frenetic nature. Please enter a valid Email address! During the Metal Head invasion in the latter part of Jak II, Vin alerted Jak that it was Kor who sabotaged the Shield Wall. The JAK2 enzyme has been the focus of research lately for treatment for myelofibrosis (MF). Jak goes to the Power Room and jump through the Warp Gate to Strip Mine to find and rescue Vin as the Metal Heads attacks. Long-term control of absolute polycythemia may be achieved by periodic phlebotomies, radioactive phosphorus, and/or chemotherapy. "[3] However he also implies that he is lonely, "If you fail, I can always use a companion in here. Jak. The Baron has a daughter, Ashelin, who was born in the Hav… Jak II (known as Jak II: Renegade in Oceania and Europe) is an open world platform third-person shooter action-adventure video game developed by Naughty Dog and published by Sony Computer Entertainment for the PlayStation 2.It is the second game of the Jak and Daxter series and is the sequel to Jak and Daxter: The Precursor Legacy.It was followed by Jak 3 a year later. In fact, patients with absolute polycythemia often have an expanded blood volume. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of … During Jak II he served as the opposing factor of Baron Praxis, and, while in disguise as an elderly human, an inside-man working for the Underground resistance movement, charged with watching over the Kid … Vin is a scientist who sends Jak on several missions outside of Haven City. The clinical signs of relative polycythemia are easily recognized and will not be further discussed here. He was the operator of the power station in Haven City, and a close ally of the Underground movement, described as one of their best informants. Language: English Location: United States Restricted Mode: Off Menu. The blood volume and red cell mass could be determined by labeling red cells radioactively or with biotin. However, secondary cardiac and renal changes due to erythrocytosis may also be observed and confound the interpretation. Splenic contraction is an unlikely cause in dogs and cats, as it only marginally increases the PCV. Hydroxyurea has also caused nail sloughing. Yon moun ou renmen. Clinical signs of absolute polycythemia are characterized by manifestations of the underlying disease process and are associated with hyperviscosity and the expanded blood volume. Krew's mission is in part (o). Jodidos huevos!! While there, Vin appears. Urs Giger Cyanosis may only be noted caudally. 2 Sipoze de moun vin antre nan asanble nou, yonn gen yon bèl rechanj sou li ak yon bag an lò nan dwèt li, lòt la tou pòv ak yon rad chire sou li. Vin, a character in the video games Jak II and Jak 3; Vin, the primary character in the Mistborn series by Brandon Sanderson; Vin Gonzales, a Spider-Man/Marvel Comics supporting character; Vin Petrol, a character in the Corner Shop Show; Places. Cats with cardiac shunting usually die before they can develop signs of polycythemia. Oh, the fun we'll have."[4]. It was also one of the first platformers to add first-person shooting and sandbox gameplay. Both are required, but you can do them in either order. A single transformed stem cell gains a selective growth advantage and becomes the predominant source of marrow precursors, and the clonality of the bone marrow cells of human patients with P. vera has been documented. 2003's "Jak II" is a Naughty Dog release, and a sequel to their prior release "Jak and Daxter: The Precursor Saga." Take your favorite fandoms with you and never miss a beat. He is the founder of the ruling dynasty in Haven City, the House of Mar , with the family crest and Precursor artifact known as the Seal of Mar . KIYÈS ou vle kòm zanmi w? In animals with absolute polycythemia, fluid administration beyond replacement may be associated with cardiopulmonary failure as these animals are completely volume expanded. From that point on, Vin could be seen at the power station operating computers, and would occasionally send Jak on missions at the strip mine and drill platform, two of which involved clearing these locations from metal head eggs. LES: Jak is a Fallen Angel and Vin is a scardy cat. Primary polycythemia appears erythropoietin independent and has often been considered synonymous with P. vera in small animals, although additional forms of primary polycythemia need to be considered. If possible, renal and other tumors/masses should be removed or treated and cardiopulmonary distress should be corrected. Polydipsia and -uria and splenomegaly has been seen in animals assumed to have P. vera and rarely with other polycythemias. However, a bone marrow aspirate for cytologic examination adds no new information, since it fails to differentiate between primary and secondary polycythemias: the myeloproliferative disease resulting in P. vera has no characteristic cytologic or pathologic features of malignancy. Vin is a very skilled technician and computer operator, stabilizing the eco grid and Shield Wall from the power station, as well as maintaining other Haven City technology. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Furthermore, an appropriate secondary polycythemia has been documented in several breeds of dogs and domestic shorthair cats with hereditary methemoglobin reductase deficiency, which results in the erythrocytes’ inability to carry oxygen. His 'friend,' Ashelin, had stopped by the Underground hideout. What the users think. In emergency situations, patients with relative polycythemia will respond to fluid therapy, whereas patients with absolute polycythemia may need to be treated by phlebotomy. The treatment of relative and absolute polycythemia is clearly different. Vin is a support character in Jak II and Jak 3. One of the newest and most promising treatments for MF is … CU offers 5 ways to follow us so your news feed will never lack new art and inspiration. 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Neurologic signs are the most common presenting complaints, but with the advent of more frequent health screens including complete blood cell counts, the erythrocytosis may be discovered earlier as an incidental finding. Furthermore, antithrombotic doses of aspirin (1 mg/kg per day) may be considered, but there is no proof that it reduces the risk of thrombosis, and higher doses may lead to increased bleeding tendencies. The target hematocrit is higher in dogs than in cats, as well as in cases with cardiopulmonary disease, but generally is greater than 50%. In cases that require multiple phlebotomies in a short period, replacement of coagulation factors and albumin with plasma may need to be considered. Jak II is a real departure from the formula that was set up in the first Jak and Daxter game. While channeling Dark Jak, Jak's skin complexion becomes a light gray with a slight purple or blue tint, his hair grows slightly longer, shaggier and spikier, and becomes a darker gray, with his goatee looking somewhat darker, and his eyes grow completely black. He also grows large, black claws, and during Ja… There are 2 Eco Wells that are hidden in newly opened areas: One is located behind the building where Vin used to hide before you rescued him. It was one of the first platformers to get rid of the item collection element and focus more on the game's story. However, if the underlying condition cannot be corrected, lowering the PCV into a safe range in patients with absolute polycythemia may be successfully accomplished with repeated phlebotomy and, if needed, chemotherapy. Jak 2 was a revolutionary game for Naughty Dog. Bay non kèk nan zanmi Jewova te genyen. This time, however, Daxter speaks up, and the leader - better known as Keira - … In most cases increased serum erythropoietin concentrations were documented or an association was established based upon the resolution of the polycythemia following the resection of the mass in animals and humans. He is deathly afraid of metal heads, constantly worried he is going to die, and in a near-constant state of panic. However, Damas' son (later revealed to be Jak before he was sent to the past) escaped. Dark blood may be exposed to air to determine if it is deoxyhemoglobin or methemoglobin. Oops! Chapter XXII: Scardy Vin. Vin Art . More difficult is the differentiation of absolute polycythemia into primary or secondary polycythemia, which depends on whether the condition is erythropoietin independent or dependent. Damas was banished to the Wasteland. 5 (4) 4 (0) 3 (1) 2 (0) 1 (0) 4.6 stars. a holographic projection of his mind. Get daily updates for video game art galleries packed with loads of concept art, character artwork, and promotional pictures. The author is the director of the non-for-profit PennGen Laboratory which is offering genetic, hematological and blood typing and compatibility testing. Vin voiced by Robert Patrick Benedict and 2 others . The other one is behind the first well (if you took my advice above) and can be accessed by taking the path around the Dark Eco lake on the side of Vin's hideout. There are no cytologically characteristic features of the bone marrow cells in P. vera as hematopoietic cells appear to fully mature. Hence, polycythemia would be more appropriately called erythrocytosis and clinically refers to an increase to an above normal red blood cell count, hematocrit or packed cell volume (PCV), and hemoglobin (Hb) concentration. P. vera, therefore, results in the accumulation of morphologically normal red blood cells, and less commonly white cells and platelets, and their progenitor cells in the absence of a definable stimulus. Torn said, it wasn't a question. Listen to all the actors who have voiced the following Jak II characters. Vin worked for the city as the operator of the eco grid and other technology. "Every time a second-hand car is bought, it is possible that some of its faults are yet to be discovered; it is a bit like buying a pig in a poke. We once again follow Jak (and his sidekick Daxter), this time in a new setting. 2 Jewova Dye chwazi kèk moun pou vin zanmi l. Pa egzanp, Abraram se te youn nan zanmi Jewova te genyen (Ezayi 41:8; Jak 2:23). Serum erythropoietin values, determined by a species-validated assay, may be elevated in cases of secondary polycythemia, but a normal to low erythropoietin level does not rule out secondary polycythemia. Similarly, chronic carbon monoxide intoxication can cause polycythemia with pink mucous membranes. He was chosen to protect the planet by the Precursors and helped build many relics and structures seen throughout both Jak II and Jak 3, including the Shield Wall and eco grid. This is, however, rarely if ever needed in clinical practice, as dehydration can be readily excluded as cause of relative polycythemia. - Duration: 30:27. roblesdegracia 91,121 views. Because of the obvious signs of dehydration, relative polycythemia is usually easily recognized and simply corrected with aggressive fluid therapy. However, his frantic personality dims a little bit when it comes to his work, as he has a sense of pride in his skills and dislikes his expertise being questioned. He is an averagely tall, lanky human, with protective eyewear, brown overalls, white shirt, and mining boots. "So, our newest recruit saved you." Daxter, his ottsel sidekick, saves him and his first thought is revenge against Baron Praxis, the ruler of Haven City. Clinical experience, however, suggests that P. vera may occur rarely compared to other forms of polycythemia. Animals with methemoglobin reductase deficiency may not need to be treated except during severe stress situations with methylene blue (1 mg/kg IV once). The hematocrit is generally only mildly increased, therefore relative polycythemia is rarely associated with signs of hyperviscosity, and the clinical features of the underlying disorder prevail. Back at Keira's garage, Jak gets a little steamed after Keira talks fondly of Erol and walks away, leaving Daxter to win the class 2 race on his own. Relative polycythemia is characterized by an elevated PCV in the presence of a normal (or even decreased) total red blood cell mass. Vin. Polycythemia vera is a myeloproliferative clonal disease that arises from a multipotent hematopoietic progenitor cell in the bone marrow. Absolute or true polycythemia is characterized by an expanded red blood cell mass. Rescue Vin at Strip Mine (**) ----- This is the first time you can choose which mission you take. He has a constant fear of Metal Heads and is a bit crazy. Secondary polycythemia refers to a group of diseases triggered by an exaggerated erythropoietin dependent stimulation of red cell production. Appropriate PCV rises are seen in high altitudes and with cardiopulmonary disease such as congenital heart defects with right to left shunts (ventricular septal defects, reversed PDA, Tetralogy of Fallot) and rarely chronic obstructive pulmonary diseases. Inappropriate secondary polycythemia of renal origin may also be rarely caused by amyloidosis, polycystic kidney disease, glomerulonephritis, and renal fibrosarcoma and lymphoma. Vin's most distinctive and impressionable personality trait is his frenetic and paranoid nature. However Vin is also very modest, giving credit to Mar when Jak says he is a genius at what he does. Baron Praxis used the strip mine as some means to provide such eco to the Metal Heads by installing eco wells and leaving them open for the taking, under the pretense to the people that he would eventually pipe them into the eco gridfor the city. New insight into the causes of primary and secondary polycythemias has been gained in human and veterinary medicine. Cyanosis or renal size abnormalities may suggest a particular organ failure as well as mechanism, and define the type of the polycythemia. Jak II 124% complete walkthrough. https://jakanddaxter.fandom.com/wiki/Vin?oldid=135647. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. 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